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Insulin aspart, marketed as NovoLog® (NovoRapid® in some regions), is a rapid-acting human insulin analog used to manage hyperglycemia in type 1 and type 2 diabetes mellitus. Engineered for rapid onset and short duration, it mimics physiological insulin secretion to control postprandial glucose spikes. This article synthesizes evidence from the British National Formulary (BNF), Lippincott Textbook of Pharmacology, and Lange Basic & Clinical Pharmacology to detail its pharmacology, clinical use, and safety profile.
Insulin aspart is structurally modified (proline replaced with aspartic acid at position B28) to accelerate absorption and action. It binds to insulin receptors, initiating:
Elderly: Conservative dosing to avoid hypoglycemia
Serious:
In-use: Store at room temperature (<30°C) for up to 28 days
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