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Semaglutide, marketed as Ozempic®, is a glucagon-like peptide-1 (GLP-1) receptor agonist administered via subcutaneous injection. It is used to manage type 2 diabetes mellitus (T2DM) and has demonstrated cardiovascular benefits. This article details its pharmacology, clinical applications, and safety profile, referencing the British National Formulary (BNF), Lippincott Textbook of Pharmacology, and Lange Basic & Clinical Pharmacology.
Semaglutide mimics endogenous GLP-1, enhancing glucose-dependent insulin secretion from pancreatic β-cells and suppressing glucagon release from α-cells (Lippincott). Key effects include:
Serious:
Discontinue if pregnancy occurs; avoid during breastfeeding (BNF).
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