Drugs, Supplies and Delivery
Gemfibrozil is a fibrate medication primarily used to manage hypertriglyceridemia and mixed dyslipidemia. This article details its mechanism of action, clinical uses, dosing guidelines, side effects, precautions, drug interactions, and generic/brand names, referencing the British National Formulary (BNF), Lippincott Textbook of Pharmacology, and Lange Basic & Clinical Pharmacology.
Gemfibrozil activates peroxisome proliferator-activated receptor alpha (PPAR-α), a nuclear receptor that regulates lipid metabolism. This activation:
Pancreatitis: Linked to rapid triglyceride reduction
Creatine Kinase (CK): Check if myalgia or muscle weakness occurs
US: Lopid, Jezil
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