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Yasmin (Ethinylestradiol/Drospirenone)
Yasmin is a combined oral contraceptive (COC) pill containing ethinylestradiol (a synthetic estrogen) and drospirenone (a synthetic progestin). Approved for contraception and other therapeutic uses, it is widely prescribed due to its unique pharmacological profile. This article explores its mechanism of action, uses, dosage, side effects, precautions, and drug interactions, referencing key pharmacological texts.
Yasmin’s contraceptive effect arises from synergistic actions of its components:
- Ovulation Suppression: Ethinylestradiol suppresses follicle-stimulating hormone (FSH), inhibiting follicular development, while drospirenone blocks the luteinizing hormone (LH) surge, preventing ovulation (Lippincott Textbook of Pharmacology).
- Cervical Mucus Thickening: Drospirenone alters cervical mucus, impeding sperm penetration.
- Endometrial Changes: Progestin thins the endometrial lining, reducing implantation potential (Lange Basic & Clinical Pharmacology).
Drospirenone, a spironolactone analogue, also exhibits anti-androgenic (reducing acne) and anti-mineralocorticoid effects (mitigating fluid retention), broadening its therapeutic applications.
