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Zinc
Zinc is an essential trace mineral that plays a critical role in immune function, wound healing, DNA synthesis, and cell division. It is vital for growth, development, and overall health. This article synthesizes information from authoritative sources, including the British National Formulary (BNF), Lippincott Textbook of Pharmacology, Lange Basic & Clinical Pharmacology, Mayo Clinic, and Harvard Medical School, to provide a detailed overview of zinc.
- Immune Support:
- Reduces the severity and duration of colds and infections (Mayo Clinic).
- Wound Healing:
- Accelerates tissue repair and reduces inflammation (Harvard Medical School).
- Skin Health:
- Treats acne, eczema, and other skin conditions (BNF).
- Growth and Development:
- Essential for childhood growth and sexual maturation (Lange).
- Antioxidant Protection:
- Reduces oxidative stress and may lower the risk of chronic diseases (Lippincott).
- Animal Products:
- Meat (beef, lamb), shellfish (oysters, crab), and poultry.
- Dairy:
- Milk, cheese, and yogurt.
- Plant-Based Sources:
- Legumes (chickpeas, lentils), nuts, seeds, and whole grains.
- Fortified Foods:
Breakfast cereals and plant-based milk alternatives
Zinc deficiency can lead to:
- Immune Dysfunction: Frequent infections and slow wound healing.
- Growth Retardation: Delayed growth and development in children.
- Skin Issues: Acne, eczema, and dermatitis.
- Hair Loss: Thinning or loss of hair.
- Neurological Symptoms: Loss of appetite, taste, or smell (Mayo Clinic).
Risk Factors:
- Poor diet, vegetarianism, alcoholism, malabsorption disorders (e.g., Crohn’s disease), and chronic illnesses.
- Normal: 70–120 mcg/dL (Mayo Clinic).
- Deficiency: <60 mcg/dL.
- Zinc Gluconate:
- Common OTC form; used for colds and immune support.
- Tablets: 10 mg, 15 mg, 50 mg.
- Zinc Sulfate:
- Used for deficiency treatment and skin conditions.
- Tablets: 110 mg (equivalent to 25 mg elemental zinc).
- Zinc Acetate:
- Used for Wilson’s disease and taste disorders.
- Zinc Picolinate:
- Highly bioavailable form for supplementation.
- Immune Support:
- Reduces cold severity and duration; recommended dose is 75–100 mg/day for short-term use (BNF).
- Wound Healing:
- Topical zinc oxide creams promote healing in burns and ulcers (Lippincott).
- Skin Conditions:
- Treats acne, eczema, and diaper rash (Harvard Medical School).
- Zinc Deficiency:
- Corrects low levels in malabsorption or dietary insufficiency (Lange).
- Wilson’s Disease:
- Reduces copper absorption in this genetic disorder (Mayo Clinic).
Daily Requirements (RDA):
- Adults: 8–11 mg/day.
- Pregnancy/Lactation: 11–12 mg/day.
Deficiency Treatment:
- Adults: 25–50 mg elemental zinc/day for 3–6 months (BNF).
Administration Tips:
- Take with food to reduce gastrointestinal side effects.
- Avoid taking with iron or calcium supplements, as they can inhibit absorption.
Zinc is generally safe but may cause:
- Mild: Nausea, vomiting, diarrhea.
- Severe (High Doses): Copper deficiency, immune dysfunction, and neurological issues (Lippincott).
- Copper Deficiency: Long-term high doses (>40 mg/day) can deplete copper levels.
- Pregnancy: Safe in recommended doses; avoid excessive intake (BNF Category: A).
Kidney Disease: Monitor zinc levels to avoid toxicity
- Antibiotics (e.g., tetracyclines, quinolones):
- Zinc reduces absorption; take 2 hours apart (Mayo Clinic).
- Iron and Calcium Supplements:
- Inhibit zinc absorption; separate doses by 2–3 hours (Lange).
- Penicillamine:
- Zinc reduces efficacy; avoid concurrent use (BNF).
- Zinc Gluconate: Cold remedies and immune support.
- Zinc Sulfate: Deficiency treatment.
- Zinc Oxide: Topical creams for skin conditions.
- Zinc Acetate: Wilson’s disease.
